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Researchers

  • Nikolay Gerasimchuk
  • Marianna Patrauchan

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Details

Project TitleAntimicrobial, thermally and visible light stable silver (I) cyanoximates that inhibit biofilm formation
Track Code2014-022
Short DescriptionNone
AbstractNone
 
TagsBiotech & Pharmaceutical
 
Posted DateJun 7, 2016 12:47 PM

Researcher

Name
Nikolay Gerasimchuk
Marianna Patrauchan

Manager

Name
Scott Davis

Background

Hospital-acquired infections are becoming more prevalent worldwide. According to the CDC, 1.7 million patients in the US acquire infections during their hospital stay, which costs $6.7 billion dollars annually. Fifty-four percent of hospital-acquired infections occur at surgical sites or in urinary tracts, and are increasingly caused by antibiotic resistant bacteria. Incorporating long lasting broad-spectrum antibacterial agents into the polymeric matrix for fixing indwelling medical devices has the potential to greatly reduce the number of hospital-acquired infections. 

Summary

Known for their antibacterial properties, silver compounds are often incorporated in implant materials, such as bioglass and bone cement in order to reduce infection occurrence rates. However, the greatest challenge with those applications is that common silver (I) inorganic compounds are either leaching out, or become reduced to elemental silver upon exposure to light and heat.

Researchers from Oklahoma State University and Missouri State University have developed novel silver compounds that significantly improve the ability of silver-incorporating biomaterials to remain stable with exposure to light and heat. This group of silver (I) cyanoximates display remarkable resistance to high intensity visible light, heat, and have a broad range of solubility (from completely insoluble to relatively soluble). Importantly, researchers have demonstrated these complexes, when incorporated into polymeric composites, possess strong antimicrobial activity by inhibiting both planktonic and biofilm growth of several diverse human pathogens. 

Potential Applications

  • Bio-implants
  • Catheters
  • Water sterilization 

Main Advantages

  • Entirely new class of compounds with a string and broad spectrum antimicrobial activity against Gram-positive and Gram-negative antibiotic resistant bacteria
  •  Water insoluble, light and thermally stable
  • Can be readily incorporated into polymeric matrixes

Stage of Development

Proof of concept has been achieved. Patent application 13/612,501 pending.

Contact Information

Please contact tdc@okstate.edu for more information.